The Centers for Disease Control and Prevention's Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update provides health care providers with recommendations on the use of PrEP to prevent HIV, including use in HIV serodifferent couples attempting to concieve. PrEP is a powerful HIV prevention tool. However, for sexually active people, no prevention strategy is 100% effective. Therefore, the guidelines also recommend that physicians encourage patients to use PrEP with other effective strategies—like using condoms, testing for HIV with partners, reducing the number of partners, and having partners who are living with HIV take antiretroviral therapy—to provide even greater protection from HIV.