The American College of Obstetricians and Gynecologists' Committee Opinion Preexposure Prophylaxis for the Prevention of Human Immunodeficiency Virus addresses the use of PrEP in combination with other proven HIV prevention methods as a useful HIV prevention strategy for people at the highest risk of acquiring HIV. It states that potential candidates for PrEP are HIV-negative women who have a male sexual partner who is living with HIV and/or women who engage in sexual activity within a high HIV-prevalence area or social network, and who have one or more of the following risk factors: Inconsistent or no condom use; diagnosis of sexually transmitted infections; engagement in transactional sex (i.e, sex for money, drugs, or other forms of payment); use of intravenous drugs or alcohol dependence or both; and/or partners of unknown HIV status with any of the factors previously listed.